As the industrial Internet of Things progresses, sensors and actuators become network-enabled and smarter. However, the increasing attack surface leads to a higher risk of cyberattacks on industrial control systems. This may endanger people and the environment, especially for systems in critical infrastructures. This report presents the research project “iSEC”, which aims to develop security solutions for low-power industrial embedded systems. The results from the threat analysis, the evaluation of Physical Unclonable Functions and cryptographic solutions are presented and a few findings described.